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The initial pro-inflammatory phase during sepsis is followed by an anti-inflammatory response resulting in immune suppression associated with T cell anergy/depletion. Since dendritic cells (DC) are potent antigen-presenting cells and play a key role in inducing the appropriate T cell response e. g. upon infection, we tested the hypothesis that DC are involved in sepsis-mediated immune suppression...
Besides advanced surgical therapy and intensive care, sepsis often leads to fatal consequences and is therefore still a major problem of modern surgery. Both, extensive complement activation and associ-ated compromised cellular defence seem to play an important role in development and progression of sepsis. Recently, a second C5a receptor (C5L2) was detected on neutrophils and proposed to function...
In human neutrophil granulocytes (PMN) endotoxin (LPS) leads to NF-κB activation and reduction of apoptosis. In this study we investigated whether transscription factors such as NF-κB, STAT3 or the proteasome regulate PMN survival after LPS-stimulation in PMN from patients with sepsis and healthy controls. PMN (1 × 106/mL), isolated from septic patients (n = 10) or healthy volunteers (n = 10)...
The limulus amoebocyte lysate (LAL) test has been used to indicate the presence of endotoxin in plasma for many years [1]. Discordant results were explained by variations in preparation, lack of sensitivity but also specifity of the test assay [2]. In 1993 Di Padova et al. [3] were able to generate a broadly cross-reactive monoclonal antibody (Mab) Wn1-222/5 recognizing the core region of E...
Aim: A selective preoperative defect in monocyte IL-12 production has been identified as a predictive factor for the lethal outcome of postoperative sepsis. In order to simplify the investigation and to better match the in vivo situation whole-blood was chosen as specimen. In the present study the value of preoperative IL-12 whole-blood levels in predicting the outcome of postoperative sepsis...
Postoperative sepsis after major visceral surgery is a severe complication with high mortality. The aim of the study was to find indicators which allow for a detection of high risk patients for septic compli-cations and early predictive parameters for a severe course of abdominal sepsis. The function of monocytes prior to surgery and its significance for postoperative sepsis was examined in 1113 patients...
Background: Lipopolysaccharide-binding protein (LBP) is an integral part of the innate immune system’s response to Gram-negative bacteria. Among other effects, the concentration of neutrophil derived BPI (bactericidal permeability increasing protein) needed to kill bacteria is reduces by 10,000-fold for it acts as an opsonin. We hypothesized that LBP-knockout (LBPko) mice will have compromised...
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